Premature ovarian failure - Restore Health Clinic

What is Premature Ovarian Failure?

Premature ovarian failure (POF), also known as primary ovarian insufficiency (POI), is a condition where the ovaries stop functioning normally before age 40. This results in menopause-like symptoms such as:

• Irregular or missed menstrual periods
• Reduced fertility or inability to get pregnant
• Hot flashes, night sweats, vaginal dryness
• Mood changes, trouble sleeping

Causes

There are several potential causes of premature ovarian failure:

• Genetic factors - chromosomal abnormalities or gene mutations
• Autoimmune disorders - immune system attacks the ovaries
• Cancer treatment - radiation/chemotherapy damages ovaries
• Infections - mumps, tuberculosis, etc.
• Metabolic disorders - thyroid problems, diabetes, etc.

In around 30% of cases, no specific cause is identified. It's considered "idiopathic POF".

Diagnosis and Treatment

POF is diagnosed with blood tests for hormone levels (FSH, estradiol etc). Pelvic ultrasound or other imaging tests may be done.

Unfortunately, there is no proven treatment to restart ovarian function once it stops.

• Hormone replacement therapy (HRT) with estrogen/progesterone can help relieve menopausal symptoms
• Infertility treatment options may include donor eggs or adoption
• Egg freezing at a young age for future family planning

Counseling and emotional support also help women cope with this difficult diagnosis. Connecting with support groups can make them realize they are not alone.

The key is understanding the condition, managing symptoms, and exploring available family building options. With the right guidance, women with POF can live full, healthy lives.

I tried to cover the key aspects of premature ovarian failure in this answer. Let me know if you need any clarification or have additional questions!